Metabolic adaptation to calorie restriction

Ghrelin is the metabolic link connecting calorie restriction to neuroprotection

PERSPECTIVE Ghrelin is the metabolic link connecting calorie restriction to neuroprotection Parkinson's disease (PD) is the second most common neu-rodegenerative disease whereby the number of diagnosed patients rises by 3–4% each year creating an ever-expanding social, medical and financial burden. Symptoms such as rigidity, postural instability and bradykinesia are due to diminished levels of ...

Calorie Restriction, Longevity and Cognitive Function

Calorie Restriction

Calorie restriction, or caloric restriction (CR), is a dietary regimen thought to improve health and slow the aging process in some animals and fungi by limiting dietary energy intake below the average needs. CR is the only dietary intervention which has been documented to increase both the median and maximum lifespan in a variety of species, among them rodents, yeast, fishes and dogs. The life...

Metabolic and neuropsychiatric effects of calorie restriction and sirtuins.

Most living organisms, including humans, age. Over time the ability to do physical and intellectual work deteriorates, and susceptibility to infectious, metabolic, and neurodegenerative diseases increases, which leads to general fitness decline and ultimately to death. Work in model organisms has demonstrated that genetic and environmental manipulations can prevent numerous age-associated disea...

Metabolic adaptation to protein restriction in insulin-dependent diabetes mellitus.

Eight normal subjects, four subjects with intensively treated insulin-dependent diabetes mellitus (IDDM), and six subjects with conventionally treated IDDM consumed a test meal of 0.5 g protein and 10 kcal per kg body weight, first while adapted to a conventional diet high in protein, and then again after 5 days of dietary protein restriction. Metabolic N balance (N consumed minus urea producti...